Cellulite come agire | BeC



Cellulite, how to treat it?

Dr. Oriana Chinni

Cellulite  (or edematous sclerotic – fibrous edematous panniculopathy) is an aesthetic condition characterized by alterations of the subcutaneous tissue, uneven fat distribution and tissue tone loss. 

What does cellulite depend on?

Sex, ethnicity, genetic and hormonal disorders, skin thickness and distribution of body fat, along with a lack of fitness and a high-fat diet, are all factors that can influence the formation of cellulite.

A body affected by cellulite presents skin with “orange peel” or “mattress” texture, but several factors may contribute to the appearance of this condition. 

Fat cells or “adipocytes” tend to increase in volume with subsequent compression of the surrounding blood vessels and the slowing down of blood circulation. It determines an inflammatory state that limits the request of oxygen and nutrients from the surrounding tissues, thus preventing liquid drainage. 

The subsequent drop of local temperature contributes to the thickening of fat clusters and it is responsible for the orange peel appearance of the skin. 

How to fight cellulite?

State-of-the-art anti-cellulite cosmetics must contain ingredients that simultaneously counteract the various causes of cellulite insurgence, i.e. agents that facilitate water drainage and endow tissues with elasticizing, vasotonic and lipolytic properties.

Awareness of the problem and the passion of BeC research laboratories for developing effective wellness products gave, birth to SiluÈ: the new formulation against cellulite beauty problems

Is a rich and fast-absorbing body cream based on all natural ingredients that can used both at day-time and night-time with a very soft touch and silky texture obtained with no silicones, thanks to its unique combination of synergic active principles, which we now look at in detail.

Thanks to extract of Fucus vesiculosus alga [1] , rich in iodine and to the extract of Pao Rosa, rich in pterocarpans, SiluÈ activates lipolysis and local lipidic metabolism. To the lipolytic effect contribute the methylxanthines, such as theophylline and caffeine [2] in a synergic way, both by enhancing adipocytes’ metabolism and by stimulating fat stock mobilization.

Indeed the 100% natural extract of Pao Rosa from Madagascar (approved by organic certification bodies) boasts diverse beneficial properties: it limits the new formation of fat cells (adipogenesis), inhibits fat stocking into adipocytes (lipogenesis); moreover increases the lipolytic effect of caffeine. Such a complex and synergic mechanism produces good results in the early stages of cellulite development as well as in more advanced stages.

Anti-oedema and draining actions are obtained by the presence of several essential oils such as Caraway, Juniper, Fennel, Lemon, Lavender, Thyme, Rosemary and Clove, endowed with anti-inflammatory properties, too. 

Such activities also promoted by Centella asiatica extract, and by Fenugreek, both endowed with draining and protective action of blood vessels. This property it’s possible also to Aescin, extract from Horse chestnut and by essential oils of Thyme, Mint and Rosemary assure homogeneity of blood perfusion and help toxins removal.

SiluÈ contains precious vegetal oils which help skin elasticity as Vitamin E, Sweet Almonds and Jojoba oils, along with Olive Unsaponifiable fraction and  hydrating agents contribute to increase skin hydration +46%  after only one month of treatment such as Hyaluronate, Saccharide Isomerate and Propandiol. The good diffusion properties of ingredients from the formulation it’s possible through indirect enzymatic mechanism with no irritation, that determine a faster cellular turnover, by the vegetal lipophilic esters from Willow and Cumin help give silkiness and smoothness to the skin.Cellulite doesn’t appear in one day and it can’t be removed in two weeks, then we do not offer miracles but verified results obtained in our R&D laboratories and confirmed by efficacy tests on human volunteers. Our common goal is to guarantee the real effect… and it works! Let’s take care of our skin’s wellness: this is the key to genuine beauty!

In Depth

[1] Hexsel D, Orlandi C, Zechmeister do Prado D. Botanical extracts used in the treatment of cellulite. Dermatol Surg. 2005 Jul;31(7 Pt 2):866-72; discussion 872.
[2] Herman A, Herman AP. Caffeine’s mechanisms of action and its cosmetic use. Skin Pharmacol Physiol. 2013;26(1):8-14.

Cyclooxygenase, lipoxygenase and the inflammatory process

Cyclooxygenase and lipooxygenase are the two families of enzymes that are commonly involved in the inflammatory process, through a complex of reactions which is called arachidonic acid cascade. This complex of reactions develops as follows: a first enzyme, a phospholipase cleaves the phospholipids of biological membranes, releasing arachidonic acid, a polyunsaturated fatty acid with 20 carbon atoms (eicosa-5Z,8Z,11Z,14Z-tetraenoic acid ; C20:4; ω-6). The arachidonic acid is then transformed by two parallel enzymatic pathways, that is, by two families of enzymes: the cyclooxygenase which transforms it into prostaglandins and thromboxanes and the lipooxygenase which transforms it into hydroperoxides which in turn transform into leukotrienes .
There are two cyclooxygenase isoforms indicated with type 1 and type 2, briefly COX-1 and COX-2. COX-1 is the enzyme present in most cells (except red blood cells), and is constitutive, that is, it is always present. COX-2 is an inducible cyclooxygenase isoform: it is constitutively present in some organs such as brain, liver, kidney, stomach, heart and vascular system, while it can be induced (i.e. developed if necessary) following inflammatory stimuli on the skin, white blood cells and muscles.
There are various types of lipooxygenase that lead to different products, the most important in the inflammatory process is 5-lipooxygenase, 5-LOX.

Prostaglandins, Thromboxanes, and Leukotrienes

Prostaglandins, Thromboxanes, and Leukotrienes are chemical messengers or mediators, that is, molecules that bring a message to specific cells and activate or deactivate metabolic responses in these cells. They, therefore, have a function similar to hormones, only that, unlike what hormones do, the chemical message is carried only at a short distance, that is, only to the cells that are in the vicinity of the place where the mediators were produced. There are different prostaglandins, different thromboxanes and different leukotrienes that carry specific messages. In many cases these act as mediators of the inflammatory process , therefore they trigger all the events that are involved in inflammation:
– vasodilation with consequent blood supply (redness),
– increased capillary permeability with consequent fluid exudation (swelling or edema),
– stimulation of nociceptive nerve signals (pain),
– on-site recall of immune system cells that attack a possible invader (chemotactic action)
– activation of the biosynthesis of fibrous tissue to strengthen or repair the affected part (even if there is no need)
– generations of free radicals that can chemically destroy an invader (but also damage our tissues, i.e. they just “shoot in the middle”).
Prostaglandins and thromboxanes, however, also play important physiological roles in normal conditions, i.e. in the absence of inflammation. For example, they regulate the secretion of mucus that protects the walls of the stomach, they regulate the biosynthesis of cartilages and synovial fluid in the joints, they regulate vasodilation, hence the correct flow of blood in the various local districts, and more.


Triglycerides are the main components of most oils and fats. These are heavy, non-volatile and little polar molecules, insoluble in water, made up of glycerol (or glycerin) esterified with three molecules of fatty acids: therefore, it is a tri-ester of glycerin, from which the name derives. Each fatty acid contains 8 to 22 carbon atoms (commonly 16 to 18) and can be saturated, mono-unsaturated or poly-unsaturated. The size of the fatty acids and their saturation determines the physical and sensorial properties of the triglycerides, which can appear as oils (liquids at room temperature) or fats (solid or semi-solid) and can have greater or less greasiness and smoothness on the skin. Unsaturated triglycerides or with shorter fatty acids are more fluid and have greater flowability.

Fatty acids (saturated, mono-unsaturated and poly-unsaturated)

The name fatty acids is commonly used to indicate those organic acids that are found in the composition of lipids, that is, in animal and vegetable oils and fats, both in the free form and in the form of esters with glycerol (e.g. in triglycerides), or they are esterified with “fatty” alcohols, that is, long chain alcohols, to form waxes. Fatty acids are carboxylic acids (formula R-COOH) which have a long carbon chain (R), unlike common organic acids such as acetic acid and propionic acid, which have 2 or 3 carbon atoms in total, respectively. Fatty acids are defined as saturatedif they do not have double carbon-carbon bonds, (called “unsaturations”), they are defined mono-unsaturated if they have only one, they are defined mono-unsaturatedpoly-unsaturated if they have two or more double bonds (see figure). The term omega-3 (ω-3) or omega-6 (ω-3), refers to the position of the first double bond starting from the bottom of the chain of carbon atoms: if the first double bond is encountered after 3 carbon atoms the fatty acid is classified as omega-3 , if after six carbon atoms omega-6 , as shown in the figure. The most common saturated fatty acids are palmitic acid (16 carbon atoms and no double bond, C16: 0) and stearic acid (18 carbon atoms, 18: 0), the most common mono-unsaturated is the oleic acid, typical of olive oil (18 carbon atoms and 1 double bond in position 9, C18: 1; ω-9), while the most common poly-unsaturated are linoleic acid and linolenic acid, progenitors respectively omega-6 and omega-3 (see figure).

Terpenes and terpenoids

Terpenes or terpenoids are a large family of natural molecules, typically containing 10 to 30 carbon atoms, which are biosynthesized from a common “brick”, isopentenyl pyrophosphate (IPP), containing 5 carbon atoms (see figure). The discovery that the repetitive brick consists of 5 carbon atoms is relatively recent, while it was once assumed that the entire family was created by repeating a brick of 10 carbon atoms, which was called “terpene”. Therefore, the molecules with 10 carbon atoms (such as limonene, see figure) were called mono-terpenes, i.e. composed of a single brick, diterpenes those with 20 carbon atoms (e.g. the cafestol that gives the aroma to the coffee), triterpenes those with 30 carbon atoms (e.g. beta-carotene). Since molecules made from 15 carbon atoms were also found (such as bisabolol), it was thought they contained a terpene and a half, and were called sesquiterpenes (from the Latin semis = half + atque = and). Today it is known that the repetitive unit is composed of 5 carbon atoms, therefore it is easy to understand how mono-terpenes contain two (see figure), sesquiterpenes three, diterpenes four, triterpenes six.